This was the first site I visited outside of Europe and the Middle East. It was a lucky choice since the area has a very distinct atmposphere from what I had known. The Quebrada is stunning in its natural setting and a very special place. In the Quebrada we visited Tilcara (where we stayed and I would recommend to stay) and nearby Purmamarca. Two special assets of the towns are their traditional colourful cemeteries filled with floral ornaments which are surprisingly cheerful, and the local Cuzco style paintings. If you want an interesting explanation about the Quechua influence on this local Baroque style (in Spanish) go to the Museum of Colonial Painting in Jujuy Capital. Local restaurants offer traditional Andean food and in some of them you can also listen to indigenous music.
Two nearby attractions I would recommend to visit while here are are the Salinas Grandes de Jujuy (second largest salt flats in the world after Uyuni, Bolivia) and Calilegua National Park.