In the Middle Ages, Genoa was one of Europe's major cities and rivalled Venice in importance and wealth. Much of that glory has faded, and today, even though it is still one of the most important ports in Italy and the whole Mediterranean, Genoa is not on most people's itinerary of Italy - unless they take a ferry to Corsica or Sardinia. That is a pity, since the Old Town and the Port are full of interesting sights and offer a lively Mediterranean ambience. I really liked the Cathedral, the Doge's Palace, and especially the fantastic Aquarium. Genoa is also an easy pick for WH collectors, since the ensemble of palaces on the Strada Nuova is really very central (and clearly signposted), even though, admittedly, they are not terribly interesting. Most cannot be visited, and those that can (there is a combined ticket) mainly feature modestly interesting art collections. By far the most beautiful of them is the Royal Palace (Palazzo Reale), a bit further down the street, which really lives up to its name with its lavish interior and pretty courtyard. For me, Genoa was definitely worth a visit - just don't go there for the WHS alone.